AMOXICILLIN/ CLARITHROMYCIN/ VONOPRAZAN MISCELLANEOUS
Clinical Criteria Summary
Exclusion Criteria
- Pregnancy
- Need for concomitant rilpivirine administration
- Serious drug-drug interactions that cannot be managed (e.g., concomitant colchicine if renal or hepatic impairment, pimozide, lurasidone, lovastatin, simvastatin, strong CYP3A inducers)
- Known prolongation of QT interval or ongoing proarrhythmic condition (e.g. uncorrected hypokalemia or hypomagnesemia, significant bradycardia, concomitant Class IA or III antiarrhythmics)
Inclusion Criteria
- Documented H.pylori by laboratory test or pathology
- Documented susceptibility to clarithromycin (If clarithromycin susceptibility cannot be documented by culture-based or molecular methods, exceptions to this criterion may be considered on a case-by-case basis with the guidance of a subject matter expert)
- At least one prior course of first-line regimen: bismuth quadruple or vonoprazan dual therapy unless not tolerated or contraindicated
- At least one course of salvage therapy with rifabutin triple therapy unless not tolerated or contraindicated