LEFAMULIN INJ,SOLN
Clinical Criteria Summary
Exclusion Criteria
- Prolonged QT interval
- Patients with history of ventricular arrhythmias
- Pregnancy (pregnancy status should be verified in women of childbearing potential) or lactation
- Concomitant receipt of strong CYP3A4 inducers (e.g. rifampin, applies to both oral and injection) or strong CYP3A4 inhibitors (applies to oral only)
- Concomitant receipt of sensitive 3A4 substrates that prolong the QT interval (e.g. pimozide)
- Concomitant receipt of Class 1a or class III antiarrhythmic agents
Inclusion Criteria
- Prescriber is an VA/VA Community Care Infectious Diseases or other facility authorized provider
- Patient has a diagnosis of community acquired bacterial pneumonia
- PORT (PSI) classification of II, III or IV
- Women of childbearing age agree to a pregnancy test and to use appropriate contraception until at least 2 days after the last dose
- Additional Inclusion Criteria (Must meet one of the following)
- Intolerance to fluoroquinolones, macrolides AND doxycycline
- Severe beta-lactam allergy AND high risk for FQ adverse events
Special Considerations/Exceptions
- Lactating women may be considered if they discard milk during treatment and for 2 days after final dose